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Job summary

Main area
PKPD respiratory research
Grade
Band 5
Contract
Fixed term: 24 months (n/a)
Hours
Full time - 37.5 hours per week (Out of hours work as required)
Job ref
339-CCS4947-CCC
Employer
North Bristol NHS Trust
Employer type
NHS
Site
Southmead Hospital
Town
Bristol
Salary
£31,049 - £37,796 per annum (FTE) or pro-rata for part time roles
Salary period
Yearly
Closing
17/09/2025 23:59

Employer heading

North Bristol NHS Trust logo

PKPD Post Doc

Band 5

 

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Job overview

To lead new evaluations regarding pharmacokinetic and pharmacodynamic (PKPD) for pulmonary optimization within the PKPD laboratory (Research Microbiology Department).

To work closely with the Consultant respiratory physician and Head Research Scientist in the PKPD lab to ensure the management of simulations is of a high quality and to take responsibility for :

High quality data

MIC studies

·         Time Kill Curve evaluations

·         Immunoassay and liquid chromatographic assays, including the operation, maintenance and management of HPLC systems within the ARL laboratory.

·         Development of PKPD models

·         Method development of respiratory agents

·         Providing specialist microbiology susceptibility and molecular tests

·         The role will also include assistance in North Bristol Trusts NIHR CRN Portfolio and other microbiology research projects. The post holder will be required to work alone and participate in regular out of hours working

Main duties of the job

Practical responsibilities

·         Implement the setup and running and, quality assure the data generated from pharmacodynamic models as designed to investigate the interactions of antibiotics on bacteria in a research setting

·         Ensure accurate data collection and analysis as appropriate using Excel and Word and specialist software such as Graph Pad Prism.

·         Measurement, analysis and quality assure antimicrobial agents used in PK/PD studies by immunoassay, liquid chromatography or bio-assay

·         Perform tests to assess the susceptibility of bacteria to antibiotics by both routine and specialist techniques, including disc methods, agar and broth dilution methods, E test, and antibiotic – antibiotic interaction studies

·         To support the line manager in the delivery of Pharma, NBT and NIHR-CRN research projects

Working for our organisation

North Bristol NHS Trust employs over 12,000 staff providing healthcare to the residents of Bristol, South Gloucestershire and North Somerset from our award-winning hospital building at Southmead.  We are the regional Major Trauma Centre, and an internationally recognised centre of excellence in a range of services and major specialities. Our vision is that by enabling our teams to be the best that they can be, we will provide exceptional healthcare, personally delivered. 

North Bristol NHS Trust values all people as individuals. We aim to be an anti-discriminatory organisation and are committed to building a team that represents a variety of backgrounds, perspectives, and skills. We welcome applicants from all underrepresented groups. 

Detailed job description and main responsibilities

Knowledge

·         A relevant science degree, or post graduate degree with equivalent specialist experience

·         1 year practical experience in PKPD in vitro modelling, MIC science is essential

·         1 year practical and appropriate theoretical knowledge of analytical techniques including susceptibility testing; determination of resistance mechanisms and bacterial identification using molecular techniques

·         Experience working in a research team is essential

·         Able to maintain and demonstrate a high level of practical competence and willingness to undertake further training as required

·         Knowledge of laboratory polices, codes of practice and professional guidelines

·         Knowledge of health and safety issues pertinent to laboratory work

 

Skills

Under the direction of the  Lead Research Clinical Scientist -

·         Organize the day to day running of the respiratory PKPD simulations

·         Undertake a range of diagnostic tests relevant to the area of work

·         Present data both written and oral including laboratory reports

·         Plan, prioritize, implement and evaluate own workload and workload for support team

·         Teach and supervise non-professionally qualified staff ( if required)

·         Use NBT Clerical and IT skills

·         Work independently and be able to develop good relationships with colleagues, and external collaborators.

·         Maintain and demonstrate a high level of practical competence and willingness to undertake further training as required

For further details / informal visits contact:

Person specification

written

Essential criteria
  • PKPD practical experience
  • Performed PhD studies
  • Microbiology practical experience
  • Experience of trouble shooting
Desirable criteria
  • Training experience
  • Working as part as a team and independently

Verbal

Essential criteria
  • PKPD knowledge
Desirable criteria
  • HPLC knowledge

Employer certification / accreditation badges

Apprenticeships logoNo smoking policyAge positiveArmed Forces Covenant (Silver Award)Care quality commission - GoodMindful employer.  Being positive about mental health.Disability confident employerBECHappy to Talk Flexible Working

Documents to download

Apply online now

Further details / informal visits contact

Name
Marie Attwood
Job title
Project Manager and Head Research Scientist
Email address
[email protected]
Telephone number
0117 4148476
Additional information

9-5 Monday through to Thursday via phone. 

Otherwise 9-5 via email Monday to Friday. 

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