Job summary
- Main area
- Science
- Grade
- Civil Service: Higher Executive Officer (HEO)
- Contract
- Permanent
- Hours
- Full time
- Part time
- Job share
- Flexible working
- Job ref
- 919-GB-310778-EXT
- Employer
- UK Health Security Agency
- Employer type
- Public (Non NHS)
- Site
- Porton
- Town
- Porton
- Salary
- £33,422 - £40,731 Per annum, Pro Rata
- Salary period
- Yearly
- Closing
- 12/04/2026 23:59
Employer heading
Research Scientist - Immunology
Civil Service: Higher Executive Officer (HEO)
Job overview
The Advanced Cellular Immunology (AIG) Group use pre-clinical non-human primate (NHP) models to assess the safety, efficacy, and immunogenicity of a range of novel vaccines and therapeutics to protect against and treat a range of respiratory diseases, including Tuberculosis a disease that was responsible for 1.2 million deaths in 2024.
Working as a scientist within ACI team, you will be involved in the analysis of blood, mucosal and tissue samples to measure the mycobacteria-specific cellular immune response at ACDP Containment Levels 2 & 3 using a range of advanced immunoassays. These will include: ELISPOT assays, multiplex bead arraybased technologies and flow cytometry assays for the interrogation of immunological memory and functional markers in innate and adaptive immune cells such as Conventional T-cell and Donor Unrestricted T-cell (DURTs) populations.
You will also be involved in the optimisation and establishment of new methods and technologies for interrogation of vaccine and infection induced immune responses using bio-archive and pre-clinical trial samples. This role will provide the opportunity to supervise ACDP2 and/or ACDP3 laboratories, maintaining a safe working environment, assessing risks, and organising the provision of consumables and reagents. There will also be some supervision of junior members of staff.
Main duties of the job
- Implement and utilise a range of methods, assays, and techniques at ACDP containment levels 2 & 3 in support of all activities associated with the TB evaluation group’s projects and to ensure project targets are met.
- Develop, optimise, and apply multiparameter cellular immunology assays for the investigation of mycobacteria-specific T-cell function and phenotype, such as polyfunctional T-cell analysis, T-cell activation, memory, and homing phenotypes.
- Apply multiplex bead array technology for the investigation of immune biomarkers as potential correlates of protection.
- Laboratory supervision including responsibility for the provision of reagents and consumables required for project area.
- Assist the project team to identify, evaluate and adapt new technologies where appropriate and to ensure that the project operates to a high scientific standard using current methods.
- Take responsibility for the supervision and training of junior staff allocated to the project as required.
- Provide reports through analysis of data using software and databases as necessary, to meet project targets and for preparation of presentations and publications.
- To perform any other duties required by the line manager commensurate with grade.
- To ensure that the project team undertakes work in accordance with UKHSA’s Code of Safety Practice and to work within any Quality Systems that are applicable to the site.
- To comply with all UKHSA policies and procedures.
Working for our organisation
We pride ourselves as being an employer of choice, where Everyone Matters promoting equality of opportunity to actively encourage applications from everyone, including groups currently underrepresented in our workforce. UKHSA ethos is to be an inclusive organisation for all our staff and stakeholders. To create, nurture and sustain an inclusive culture, where differences drive innovative solutions to meet the needs of our workforce and wider communities. We do this through celebrating and protecting differences by removing barriers and promoting equity and equality of opportunity for all. Please visit our careers site for more information https://gov.uk/ukhsa/careers
Detailed job description and main responsibilities
Please note that this is a research scientist post and is not a suitable position for those wishing to complete their BMS portfolio and HCPC registration.
Essential criteria:
- Education to BSc level (or equivalent) in an appropriate biological science
- Competency in relevant immunology techniques and methods acquired through previous employment or postgraduate study.
- Demonstrable experience of developing and applying multiparameter flow cytometric assays for the investigation of the cellular immune response and phenotype
- Competency working at ACDP containment level 3.
- Experience of working with in vivo models of M. tuberculosis, and a detailed knowledge of M.tb infection, immunology, vaccines and therapeutics.
- Experience of complex data analysis, presentations, reports & publication.
- Good communication skills. Able to work flexibly to meet deadlines. Ability to work in teams and independently. Self-motivating, organised, and meticulous. Willing to undertake further training.
- Experience in scientific writing e.g creating reports, and publications. Experience of creating and giving presentations.
- Experience of ACDP2 / ACDP3 laboratory management and/or supervision.
- An understanding of and commitment to equality of opportunity and good working relationships.
Selection Process Details (Success Profiles)
This vacancy is using Success Profiles and will assess your Behaviours, Experience and Technical skills.
Stage 1: Application & Sift
Success profiles Success Profiles - GOV.UK
You will be required to complete an application form. You will be assessed on the listed (10) essential criteria, and this will be in the form of a:
- Application form (‘Employer/ Activity history’ section on the application)
- 1500 word supporting statement.
This should outline how you consider your skills, experience and knowledge provide evidence of your suitability for the role, with reference to the essential criteria.
You will receive a joint score for your application form and statement. (The application form is the kind of information you would put into your C.V –please be advised you will not be able to upload your CV. Please complete the application form in as much detail as possible). Please do not email us your CV.
Longlisting:
In the event of a large number of applications we will longlist into 3 piles of:
- Meets all essential criteria
- Meets some essential criteria
- Meets no essential criteria
If used, the following will proceed to shortlisting:
- Meets all essential criteria
- Meets some essential criteria
Shortlisting:
In the event of a large number of applications we may conduct an initial sift, on the lead criteria of:
- Education to BSc level (or equivalent) in an appropriate biological science.
- Competency in relevant immunology techniques and methods acquired through previous employment or postgraduate study
- Experience of working with in vivo models of M. tuberculosis, and a detailed knowledge of M.tb infection, immunology, vaccines and therapeutics.
If you are successful at this stage, you will progress to interview & assessment.
Feedback will not be provided at this stage.
Stage 2: Interview
You will be invited to a single face to face interview at UKHSA Porton.
Behaviours, Experience and Technical skills will be tested at interview.
The Behaviours tested during the interview stage will be:
- Working Together
- Managing a Quality Service
- Delivering at Pace - Lead behaviour
Once this job has closed, the job advert will no longer be available. You may want to save a copy for your records.
Location
This role is being offered as office/lab based at our site in Porton.
You will be required to have a Counter Terrorism Check security vetting check as a minimum. For meaningful National Security Vetting checks to be carried out individuals need to have lived in the UK for a sufficient period of time. You should normally have been resident in the United Kingdom for the last 3 years as the role requires Counter Terrorism Check (CTC) clearance. UK residency less than the outlined periods may not necessarily bar you from gaining national security vetting and applicants should contact the Vacancy Holder/Recruiting Manager listed in the advert for further advice.
Security Clearance Level Requirement
Successful candidates must pass a basic disclosure and barring security check before they can be appointed.
Successful candidates must meet the security requirements before they can be appointed. The level of security needed is Counter-Terrorist Check.
Eligibility Criteria – External
Open to all external applicants (anyone) from outside the Civil Service (including internal applicants).
Salary Information
If you are successful at interview, and are moving from another government department, NHS, or Local Authority, the relevant starting salary principles for level transfers or promotions will apply. Otherwise, roles are offered at the pay scale minimum for the grade, but in exceptional circumstances there may be flexibility if you are able to demonstrate you are already in receipt of an existing, higher salary. Pay increases are through the relevant annual pay award for the role and terms.
Person specification
Application form and supporting statement
Essential criteria
- Application form and supporting statement
Behaviours
Essential criteria
- Working Together
- Managing a Quality Service
- Delivering at Pace - Lead behaviour
Documents to download
Further details / informal visits contact
- Name
- Gurkamal Bhambra
- Job title
- Resourcing
- Email address
- [email protected]
- Additional information
For more information you can also contact - [email protected]
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